http://www.breastpathologyconsults.com/blog/ask_the_pathologist/her2-testing-errors/ Just another WordPress weblog Thu, 27 May 2010 14:46:21 +0000 http://wordpress.org/?v=2.9.2 hourly 1 http://www.breastpathologyconsults.com/blog/ask_the_pathologist/her2-testing-errors/comment-page-1/#comment-15 drlawton Mon, 20 Oct 2008 20:29:57 +0000 http://www.breastpathologyconsults.com/blog/?p=378#comment-15 I completely agree. There are many studies, usually from large clinical trials, that show that local pathology labs and the central pathology review study labs disagree frequently on HER2 status. One of the most significant is the Breast Intergroup (N9831) study where the central review lab only agreed on 74% of HER2 IHCs and 66% of HER2 FISH! I completely agree. There are many studies, usually from large clinical trials, that show that local pathology labs and the central pathology review study labs disagree frequently on HER2 status. One of the most significant is the Breast Intergroup (N9831) study where the central review lab only agreed on 74% of HER2 IHCs and 66% of HER2 FISH!

]]> http://www.breastpathologyconsults.com/blog/ask_the_pathologist/her2-testing-errors/comment-page-1/#comment-14 Ole Eichhorn Mon, 20 Oct 2008 13:52:21 +0000 http://www.breastpathologyconsults.com/blog/?p=378#comment-14 Definitely, get a second opinion from another pathology lab. Scoring Her2 is difficult and subjective, and it isn't unusual for two pathologists to disagree on the same case. This is important enough to get right; you want to take Herceptin if it can help you, but you don't want to expose yourself to the side effects and expense if it can't. Definitely, get a second opinion from another pathology lab. Scoring Her2 is difficult and subjective, and it isn’t unusual for two pathologists to disagree on the same case. This is important enough to get right; you want to take Herceptin if it can help you, but you don’t want to expose yourself to the side effects and expense if it can’t.

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