Archive for the ‘Ask the Pathologist’ Category

Estrogen Receptor Staining in Breast Cancer

Question: I recently had a breast biopsy with invasive ductal carcinoma, grade 3 and ductal carcinoma in situ. My report said “the carcinoma is estrogen and progesterone receptor negative (<5%) and negative for her2/neu over-expression (1+).” I read online that sometimes even less than 5% could still be positive for the estrogen receptor. [...]

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LCIS on Core Biopsy

Question: Hi I Had a sterotatic biopsy that revealed On the pathology report that I picked up said A. Columnar cell lesion with focal microcalcifications B. Lobular carcinoma in situ. I am so confused My doctor said I have DCIS but its lobular. Treatment plan is  lumpectomy and lymph node aspiration and then 5 years of [...]

Focal ADH on Core Biopsy

Question: Hello, I just received the results of my core biopsy, I would like you opinion on it. Proliferated fibrocystic changes comprised of ductal epithelial hyerlasia with focal atypia, duct single minute microcalcification seen in benign fibrotic tissue. Patient needs surgery consult for breast biopsy. At this point, what do you think my risk is for cancer? I [...]

Atypical Ductal Hyperplasia and Core Biopsy

Question: After several years of mammograms showing mild calcifications, this year I was informed that the radiologist saw some mild changes in the calcifications. I did another mammogram, followed by a core biopsy. The initial report came back benign, but the final came back as atypical ductal hyperplasia. I am now scheduled [...]

Margins on Lumpectomy

Question: Four weeks ago I had a core biopsy with ductal carcinoma in situ and recently had a lumpectomy. My doctor said there was 2.2 cm of DCIS, high grade with necrosis, margins negative, estrogen receptor negative. He is suggesting radiation therapy but when I went for a second opinion, the pathologist said [...]

Core Biopsy of Atypical Micropapillary Hyperplasia and Need for Surgical Biopsy

Question: I had a stereotactic core biopsy of cluster of calcifications in the upper inner left breast. Path diagnosis columnar cell change and hyperplasia with focal atypical micropapillary hyperplasia with microcalcifications. surgicial excision is recommended. From my understanding this is not cancer but has the potential to be cancer down the road. I [...]

Equivocal HER2 Results

Question: I am in the Uk and my wife (42) has Grade 2 breast cancer 2 nodes er+ and pr + my question is about her path report: the HER2 was registered at 2.2 after the FISH test – does this mean that herceptin will work or is it to borderline to benefit? As the [...]

Changes Between Core Biopsy and Surgery

Question: I have been diagnosed with invasive ductal carcinoma. The biopsy results said the tumor was ER and PR positive, and HER2 negative, and a grade 2. However, after surgery, the pathology report said ER positive, PR negative, and didn’t mention the HER2 status at all. It also changed the grade down to a 1. [...]

Sarcomatoid Carcinoma

Question: What is a sarcomatoid carcinoma? My core biopsy report said “invasive carcinoma with spindle cell features, cannot rule out sarcomatoid carcinoma.”