Question:  Can you help me understand this report?
Breast Right, biospy:
Infiltrating ductal carcinoma
SBR/Nottingham grade 2/3
Tubular score 2.
Nuclear score 2.
Mitotic score 2 (focal).
No evidence of angiolymphatic invasion
Cancerization og lobules
Ductal carcinoma in situ
Solid, papillary and cribriform patterns
Nuclear grade 2-3
Comedonecrosis present
Microcalcifications associated with in situ malignancy
Immunostains -
Estrogen receptor – diffuse strong positivity in 97% of tumor cell nuclei
Progesterone receptor [...]

Question: In 2006, I had lumpectomy and radiation in right breast following diagnosis of DCIS.  I was 38.  No family history.  First mammogram.  Margins were clear.  I have had MRIs every six months alternating with mammograms every six months.  Two weeks ago, I had a stereotatic biopsy that indicated ADH in the left breast [...]

Question: I looked for a way to post on your ask the pathologists forum but was unable so here is my question.  I noticed a lump a few months ago and saw my primary care MD, sent for a mammagrom and US.  Mammagram totally normal, no calcifications, US saw the mass and a biospy was [...]

Question: I am 56 years old and I go for my mammogram every year and my doctor said there were some calcificatons in my right breast and recommends biopsy. So I had a needle biopsy that showed “lobular carcinoma in situ” that is what the report said. He said I needed surgery which I dont [...]

A recent news release from Genomic Health, Inc. indicates preliminary data shows that the Oncotype DX® test can provide a score predicting risk of local recurrence in patients with a diagnosis of ductal carcinoma in situ (DCIS).
DCIS is a very heterogeneous disease and there is disagreement in the breast care community as to how to [...]

Question: Hello, and thanks for taking the time to answer my questions.
March 29th first biopsy done, clinical information and history: Bloody nipple discharge left breast for 20 months, papilloma suspected, mammogram clear. Diagnosis after excision: 1. Low grade DCIS 2. Focal proliferative fibrocystic changes and small intraductal papilloma 3. DCIS [...]

Question: I am 40 years old and had my first mammogram 2 months ago. It showed a 5 mm area of micro calcifications. I had a stereotactic vacuum assisted biopsy and 8 samples were retrieved. The histopath came back as DCIS – cribriform, clinging, with a nuclear grade of 2 out of 3. The slides [...]

I have uploaded a pdf version of our course on high risk lesions on breast core biopsy that we gave last year in San Diego.  We used an audience response system so if you follow through the slides you’ll see the questions we asked of the audience and the responses that we received in real [...]

I recently gave a talk on second opinions in breast pathology at the 21st Annual Conference of the National Consortium of Breast Centers in Las Vegas. A modified version of that talk is available here as a pdf:
Second_Opinion_Pathology
The first part of the talk covers some of the data in the literature and the second part [...]

In a recent issue of the journal Cancer there are two interesting articles looking at two types of radiation therapies vs. no radiation for a subset of patients with DCIS.
This has long been a controversy amongst breast care specialists.  Does all DCIS following lumpectomy need to be treated by radiation? Or is there a subset [...]