Question: I recently had a breast biopsy with invasive ductal carcinoma, grade 3 and ductal carcinoma in situ. My report said “the carcinoma is estrogen and progesterone receptor negative (<5%) and negative for her2/neu over-expression (1+).” I read online that sometimes even less than 5% could still be positive for the estrogen receptor. [...]
Question: Hi I Had a sterotatic biopsy that revealed On the pathology report that I picked up said A. Columnar cell lesion with focal microcalcifications B. Lobular carcinoma in situ. I am so confused My doctor said I have DCIS but its lobular. Treatment plan is lumpectomy and lymph node aspiration and then 5 years of [...]
Question: Hello, I just received the results of my core biopsy, I would like you opinion on it. Proliferated fibrocystic changes comprised of ductal epithelial hyerlasia with focal atypia, duct single minute microcalcification seen in benign fibrotic tissue. Patient needs surgery consult for breast biopsy. At this point, what do you think my risk is for cancer? I [...]
Question: Four weeks ago I had a core biopsy with ductal carcinoma in situ and recently had a lumpectomy. My doctor said there was 2.2 cm of DCIS, high grade with necrosis, margins negative, estrogen receptor negative. He is suggesting radiation therapy but when I went for a second opinion, the pathologist said [...]
Question: I had a stereotactic core biopsy of cluster of calcifications in the upper inner left breast. Path diagnosis columnar cell change and hyperplasia with focal atypical micropapillary hyperplasia with microcalcifications. surgicial excision is recommended. From my understanding this is not cancer but has the potential to be cancer down the road. I [...]
There is controversy in the breast health care community about using the term “carcinoma” for a non-invasive tumor (DCIS or LCIS). I want to share with you the abstract from the NIH State-of-the-Science Conference Statement on Ductal Carcinoma in Situ which was just published in the Journal of the National Cancer Institute. There is a [...]
I’ve written before about the controversy over lobular carcinoma in situ (LCIS) and whether it is just a marker of increased risk or possibly a precursor to invasive carcinoma, like ductal carcinoma in situ (DCIS). The reason it was felt to be just a marker of increased risk was that most early studies showed that [...]
I wanted to take some time to write about one of the most challenging areas in breast pathology and one that I receive countless questions about–distinguishing atypical ductal hyperplasia (ADH) from ductal carcinoma in situ (DCIS). While this may seem like an academic issue that doctors argue about it has MAJOR clinical implications for [...]
Question: My core biopsy showed DCIS and there was an area that the doctor said was “suspicious for microinvasion.” I had a mastectomy and sentinel node biopsy–large area of DCIS but no invasion, my node was negative. I’m worried about the “microinvasion” and that I could have invasive carcinoma somewhere.
I have received quite a lot of questions about lobular carcinoma in situ (LCIS) and I am glad that patients are finally drawing more attention to this disease. Since I started my career in breast pathology this has been one of the most interesting areas of breast cancer research for me. Finally, more attention is [...]
