Question:  Can you help me understand this report?
Breast Right, biospy:
Infiltrating ductal carcinoma
SBR/Nottingham grade 2/3
Tubular score 2.
Nuclear score 2.
Mitotic score 2 (focal).
No evidence of angiolymphatic invasion
Cancerization og lobules
Ductal carcinoma in situ
Solid, papillary and cribriform patterns
Nuclear grade 2-3
Comedonecrosis present
Microcalcifications associated with in situ malignancy
Immunostains -
Estrogen receptor – diffuse strong positivity in 97% of tumor cell nuclei
Progesterone receptor [...]

Question: Hello: I am a 50 year old premenopausal female. I had a 2.5 mm tubular carcinoma diagnosed in Dec 2010 and had a simple mastectomy and neg SNB. I then had a prophylactic mastectomy in March of the other side. There were atypical hyperplastic lobular and ductal cell changes in the remainder of [...]

Question: Pathologist gave a diagnosis of Invasive ductal cancer grade 1 (2/2/1), however when asked said it was a tubular cancer are these two different? thank you

Question: What is the difference between invasive lobular and ductal carcinoma? My first biopsy I had at my ultrasound said “invasive lobular carcinoma grade 2/3″ and my surgery biopsy said “invasive ductal carcinoma grade 2/3″. Does this make any difference?

Question: Hello, and thanks for taking the time to answer my questions.
March 29th first biopsy done, clinical information and history: Bloody nipple discharge left breast for 20 months, papilloma suspected, mammogram clear. Diagnosis after excision: 1. Low grade DCIS 2. Focal proliferative fibrocystic changes and small intraductal papilloma 3. DCIS [...]

Question: I am 40 years old and had my first mammogram 2 months ago. It showed a 5 mm area of micro calcifications. I had a stereotactic vacuum assisted biopsy and 8 samples were retrieved. The histopath came back as DCIS – cribriform, clinging, with a nuclear grade of 2 out of 3. The slides [...]

There is a recent study published in the September 23 issue of Breast Cancer Research that looked at changes in prognostic markers (estrogen/progesterone receptor and HER2/neu) between primary breast cancers and metastatic lesions. If you click on the Breast Cancer Research link it will provide you with the abstract.  The full article is temporarily free from [...]

Question: I recently had a breast biopsy with invasive ductal carcinoma, grade 3 and ductal carcinoma in situ. My report said “the carcinoma is estrogen and progesterone receptor negative (<5%) and negative for her2/neu over-expression (1+).” I read online that sometimes even less than 5% could still be positive for the estrogen receptor. [...]

Everyone has heard of the importance of estrogen and progesterone receptors in breast cancer–but how many of you have heard of the possible role of androgen receptors (AR) in breast cancer?
I have a particular interest in this subject as we published an article several years ago that found AR positivity in 49% of estrogen receptor [...]

I wanted to take some time to write about one of the most challenging areas in breast pathology and one that I receive countless questions about–distinguishing atypical ductal hyperplasia (ADH) from ductal carcinoma in situ (DCIS). While this may seem like an academic issue that doctors argue about it has MAJOR clinical implications for [...]