Question:  Can you help me understand this report?
Breast Right, biospy:
Infiltrating ductal carcinoma
SBR/Nottingham grade 2/3
Tubular score 2.
Nuclear score 2.
Mitotic score 2 (focal).
No evidence of angiolymphatic invasion
Cancerization og lobules
Ductal carcinoma in situ
Solid, papillary and cribriform patterns
Nuclear grade 2-3
Comedonecrosis present
Microcalcifications associated with in situ malignancy
Immunostains -
Estrogen receptor – diffuse strong positivity in 97% of tumor cell nuclei
Progesterone receptor [...]

Question: Pathologist gave a diagnosis of Invasive ductal cancer grade 1 (2/2/1), however when asked said it was a tubular cancer are these two different? thank you

Question: What is the difference between invasive lobular and ductal carcinoma? My first biopsy I had at my ultrasound said “invasive lobular carcinoma grade 2/3″ and my surgery biopsy said “invasive ductal carcinoma grade 2/3″. Does this make any difference?

There is a recent study published in the September 23 issue of Breast Cancer Research that looked at changes in prognostic markers (estrogen/progesterone receptor and HER2/neu) between primary breast cancers and metastatic lesions. If you click on the Breast Cancer Research link it will provide you with the abstract.  The full article is temporarily free from [...]

Question: I recently had a breast biopsy with invasive ductal carcinoma, grade 3 and ductal carcinoma in situ. My report said “the carcinoma is estrogen and progesterone receptor negative (<5%) and negative for her2/neu over-expression (1+).” I read online that sometimes even less than 5% could still be positive for the estrogen receptor. [...]

In the online “early view” section of the journal Cancer there is a new research article proposing that using three currently-used immunohistochemical breast markers in a group of patients who received neoadjuvant chemotherapy, doctors can sub-type cancers similar to those described by molecular profiling.  They also suggest these sub-types are associated with different responses to treatment and overall survival. [...]

Question: I am in the Uk and my wife (42) has Grade 2 breast cancer 2 nodes er+ and pr + my question is about her path report: the HER2 was registered at 2.2 after the FISH test – does this mean that herceptin will work or is it to borderline to benefit? As the [...]

Question: I have been diagnosed with invasive ductal carcinoma. The biopsy results said the tumor was ER and PR positive, and HER2 negative, and a grade 2. However, after surgery, the pathology report said ER positive, PR negative, and didn’t mention the HER2 status at all. It also changed the grade down to a 1. [...]

Question: What is a sarcomatoid carcinoma? My core biopsy report said “invasive carcinoma with spindle cell features, cannot rule out sarcomatoid carcinoma.”

Everyone has heard of the importance of estrogen and progesterone receptors in breast cancer–but how many of you have heard of the possible role of androgen receptors (AR) in breast cancer?
I have a particular interest in this subject as we published an article several years ago that found AR positivity in 49% of estrogen receptor [...]