Question: I recently had a breast biopsy with invasive ductal carcinoma, grade 3 and ductal carcinoma in situ. My report said “the carcinoma is estrogen and progesterone receptor negative (<5%) and negative for her2/neu over-expression (1+).” I read online that sometimes even less than 5% could still be positive for the estrogen receptor. [...]

In the online “early view” section of the journal Cancer there is a new research article proposing that using three currently-used immunohistochemical breast markers in a group of patients who received neoadjuvant chemotherapy, doctors can sub-type cancers similar to those described by molecular profiling.  They also suggest these sub-types are associated with different responses to treatment and overall survival. [...]

Question: I am in the Uk and my wife (42) has Grade 2 breast cancer 2 nodes er+ and pr + my question is about her path report: the HER2 was registered at 2.2 after the FISH test – does this mean that herceptin will work or is it to borderline to benefit? As the [...]

Question: I have been diagnosed with invasive ductal carcinoma. The biopsy results said the tumor was ER and PR positive, and HER2 negative, and a grade 2. However, after surgery, the pathology report said ER positive, PR negative, and didn’t mention the HER2 status at all. It also changed the grade down to a 1. [...]

Question: What is a sarcomatoid carcinoma? My core biopsy report said “invasive carcinoma with spindle cell features, cannot rule out sarcomatoid carcinoma.”

Everyone has heard of the importance of estrogen and progesterone receptors in breast cancer–but how many of you have heard of the possible role of androgen receptors (AR) in breast cancer?
I have a particular interest in this subject as we published an article several years ago that found AR positivity in 49% of estrogen receptor [...]

Question: My pathology results showed my cancer was 3+ but FISH was done too and it showed a 1.7 so my doctor said I am not positive and therefore don’t qualify for Herceptin. From what I read 3+ is positive.

Question: I am 33 years old with a mother and aunt all with breast cancer. I was diagnosed with IDC, grade III two months ago. I also tested positive for BRCA-1. However, my cancer was not the usual type according to my doctor–it was not the “triple negative” type and so I [...]

Question: What does triple negative mean regarding breast cancer? My doctor told me that all of the special studies the lab performed on my tumor were negative and that means it can be a more aggressive type of cancer.

Question: My breast biopsy report said I have ductal carcinoma in situ, high grade with comedonecrosis; estrogen and progesterone receptor positive and her-2/neu 3+ over-expressed. My doctor referred me to a radiation therapy doctor and recommends I take Tamoxifen but not chemotherapy because the her2/neu result shouldn’t have been run on my cancer. [...]